Molecularly imprinted soft contact lenses as chloramphenicol delivery systems

Drug delivery through soft contact lenses.

Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both mo...

dummy molecularly imprinted polymer as a new omeprazole delivery system

Molecularly imprinted polymers as the future drug delivery devices.

In recent years, the investigations of new drug delivery systems have been directed on the development of some "intelligent" drug delivery devices that are able to directly respond to the patient's individual needs. New drug delivery systems should maximize the efficiency of administrated therapeutic agents and improve the patient's quality of life. Introduction of the new drug delivery devices...

Molecularly imprinted microspheres as antibody binding mimics

Molecular imprinting is an emerging technique for preparing artificial antibodies that have potential applications in affinity-based separations, biomimetic sensors and assays. The conventional imprinting methods either deliver a monolith that is mechanically ground to irregular particles — a time-consuming process with low yield, or involves complicated polymerization process by which spherica...

Nanopatterning molecularly imprinted polymers by soft lithography: a hierarchical approach.

We use soft lithography to pattern molecularly imprinted polymers (MIPs) at the nanoscale. Patterning occurs via a micro transfer molding process associated with an edge effect. We show using fluorescence microscopy that the nanopatterned synthetic receptors specifically recognize and bind a model target, dansyl-l-phenylalanine. We also demonstrate using AFM a specific swelling of the MIP patte...